In the Newton family home, George, Alice, Ryce, Ted, Emily, and Beethoven are all well adjusted to living together. Beethoven sneaks out and meets Missy, a beautiful female St. Bernard, and her owner Brillo. Regina, Brillo's future ex-wife, arrives, takes Missy, and is seeking $50,000 in the settlement. She has retained full custody of Missy and only plans to transfer her to Brillo once the divorce is finalized.