A few years after the events of the Dr. Dolittle (film), Dr. John Dolittle's (Eddie Murphy) work as a veterinarian who can talk to animals has made him famous, and he often takes trips around the world to perform his skills. One night, John comes home from France and gives his wife a present from Paris. He also gives his daughter, Maya (Kyla Pratt), a chameleon named Pepito (voice of Jacob Vargas). Also, Charisse's (Raven-Symoné) sixteenth birthday is coming today, but she is also not doing well in her classes. As a punishment, John takes her phone away. Later on, Charisse's boyfriend, Eric (Lil Zane), comes over and decides to join the family at the birthday party. During all this, a opossum (voice of Isaac Hayes) and a raccoon, Joey (voice of Michael Rapaport), approach John and tell him that their boss, the Godbeaver, wants to see him. The next day, John meets the God beaver (voice of Richard C. Sarafian), who shows him that the forest is being cut down. John plans to save the forest by getting an endangered female Pacific western bear together with a male to save their species.