Ateş Hekimoğlu is a successful doctor in his 40s. He works as a specialist in infectious diseases and nephrology at the hospital run by his girlfriend Ipek. The most well-known characteristic of Ateş Hekimoğlu is that he conducts research by focusing on diseases without establishing one-to-one relationships with patients. Each new complex case is provocative and exciting, like a puzzle waiting for him to be solved. While Ateş Hekimoğlu increases his reputation day by day with his diagnoses and treatments, his inability to keep up with the hospital layout often leaves the she is hospital administrator Ipek in a difficult situation. Ipek she is one of the two people who understands and can tolerate Hekimoğlu's tough character. The other is Orhan, the Oncology Specialist, and Hekimoğlu's friend in high school and university. Hekimoğlu examines the diseases as a detective and carries out these studies together with a team of 3 specialist doctors.