A royal from a sacred tribe combines Qing Nang Shu with Eastern and Western practices to cure the sick and save the dying. When Ye Yunshang, a young woman from a family of doctors, barges into their territory, he saves her from trouble and ends up running away with her. His journey takes him to a place afflicted by a rare kind of the plague. Despite the trials, he goes on a road to becoming a master of medicine all whilst finding love.