Five years after the events of the previous film, Gaylord "Greg" Focker is preparing to celebrate his twins Samantha and Henry's fifth-birthday party. Things seem to go awry when Greg's father-in-law Jack Byrnes visits. Recently, Jack has been diagnosed with a heart condition and become embittered by his daughter Debbie's divorce from her husband Bob (their marriage was the social event in Meet the Parents and how Jack and Greg met), for cheating on her with a nurse. Jack's original plan was to declare Bob his successor as head of the Byrnes family, but he decides to pass the role to Greg, naming him "The Godfocker". Despite Greg reluctantly accepting the role, Jack resumes his spying on him and begins to suspect him of infidelity when he sees him with drug representative Andi Garcia, who openly flirts with him, and the presence of Sustengo erection pills in Greg's house prompts Jack to think Greg is no longer sexually attracted to his wife Pam. Furthermore, Jack starts to doubt Greg's ability to provide for his family when he appears reluctant to send his children to a private school.