A water-borne virus has led to a widespread outbreak of zombies in San Francisco. A group of survivors, including Dr. Lynn Snyder (Mariel Hemingway) and others, create a refuge on Alcatraz Island. Snyder receives communications from Dr. Arnold (French Stewart), a scientist conducting experiments to create a cure for the virus. Meanwhile, Dr. Dan Halpern (LeVar Burton), another of the refugees, is studying parts culled from the bodies of the zombies, but he is unable to make much headway because he only has access to 'dead' zombies. His research is further hindered when Caspian (Danny Trejo) and other refugees burn the zombie corpses being stored on the island.