Frances Mayes is a San Francisco writer whose seemingly perfect life takes an unexpected turn when she learns that her husband has been cheating on her. The divorce—and the loss of her house to her ex-husband and his much-younger, pregnant new partner—leaves her depressed and unable to write. Her best friend Patti, a lesbian who is expecting a child, is beginning to think Frances might never recover. She urges Frances to take an Italian vacation to Tuscany using the ticket she purchased before she became pregnant. At first Frances refuses, but after another depressing day in her gloomy apartment, she decides that it's a good idea to get away for a while.