For the past 13 years, Herbert West (Jeffrey Combs) has been serving a prison sentence due to a murder at the hands of one of his zombies. With what scant supplies he has on hand in the prison medical center, Dr. West has been capable of performing only extremely basic experiments on rats. However, his lack of supplies does not prevent him from uncovering a key element in his re-animation process. Dr. West has discovered "NPE" (Nano-Plasmic Energy), an energy that can be extracted from the brain of a living organism through an electrocution-like process, to be stored in a capsule resembling a small light bulb. The capsule can then be connected to a corpse and used in conjunction with West's previously developed reagent to restore the former dead to a lifelike state. The NPE prevents the degeneration seen in previous instances, where the reanimated are nothing more than mindless zombies. Used together with the re-agent, reanimated corpses regain their skills, memories, and motor functions and nearly fully resemble normal humans.