Five years after the events of ''Dracula II: Ascension'', Father Uffizi and Luke (Jason London) discover that Dracula (Rutger Hauer) has returned with Elizabeth (Diane Neal) to his castle in the Carpathian Mountains. However, fearing that Uffizi has been tainted by Dracula, Cardinal Siqueros (Roy Scheider) refuses to give Uffizi his blessing for the mission. Uffizi defrocks himself and sets out with Luke to Bucharest.