Frontiersman Old Surehand (Stewart Granger) and his faithful friend Old Wabble (Milan Srdoc) are on the trail of a cold-blooded killer with the nickname 'The General' (Larry Pennell), who murdered Old Surehand's brother. On the way Old Surehand and Old Wabble are involved in the running conflict between settlers and the Comanches. Old Surehand can count on the support of his friend and blood brother Winnetou (Pierre Brice), the amiable chief of the Apaches. Bandits commanded by The General rob a train and try to put the blame on the Comanches. When the son of the Comanche chief is killed in town by a sniper, only Old Surehand and Winnetou are able to prevent a war between the Comanches and settlers.