Paul Stanton (Mulroney) and his wife Diane (Diane Kruger) are a couple whose daughter is dying from a rare degenerative lung condition. The only thing that can save her life is a lung transplant from an organ donor. The movie starts when the donated lung fails to arrive correctly. The movie goes back and forth between the present and the events leading up to it. In the present day, Paul goes to Juarez, Mexico to find a man called Dr. Navarro. After leaving his cell number at many local hospitals, somebody finally contacts Paul.