The film is set in a rundown, crime ridden neighborhood of Istanbul dubbed "Cholera Street" (Kolera Sokağı). Salih is a mechanic and son of a respected barber Ali. A woman Tina arrives at Cholera street where she takes up residence and works as a prostitute. Deniz is a gangster who gives himself the nickname "Reiss" ("Chief"), tries to take control of the neighbourhood through intimidation.