Manamantha follows the lives of 4 people from different paths and ambitions. The first person is shown to be Sai Ram (Mohanlal), who is the Assistant Manager of Vijetha Super Market in the Bheemili City of Vishakhapatnam, Andhra Pradesh. He lives with his uncle Sadha Shivam Reddy alias Babai (Chandra Mohan (Telugu actor)). He is always appreciated by his Manager Venkat (Paruchuri Venkateswara Rao) for his innovative ideas. But Vishwanath (Harsha Vardhan) always feels jealous of him. The next person is shown to be Mahitha (Raina Rao), a school graduating girl who has Bhushan (Vennela Kishore) as class teacher and Raghavendra Rao Sharma (Nassar) as principal. She is a Hyderabad-based girl. She hangs out with number of friends. The third person is shown to be Abhiram (Viswant Duddumpudi), who is a Computer-Engineer from Nanakramguda background, which is an IT area. He loves his friends and his lover Aira (Anisha Ambrose), who too falls in love with him for his good attitude towards humans. The last person is shown to be Gayathri (Gautami), who is a house wife from Koti and lives with Lakshmi (Urvashi), her neighbour. She always finds it difficult to run life as she has no enough money for her family. But she is always energized by her old professor (Gollapudi Maruti Rao) and she has a great respect for him. One day, Sai Ram meets Dass (P. Ravi Shankar), a local moneylender and befriends him to teach his co-worker Vishwanath a lesson. He is soon promoted as the Manager of the Super Market for his new innovative ideas. And Venkat feels happy for him. To celebrate his success, Sai Ram and his uncle go for a tour to Hyderabad and they drink in a bar. He soon receives a phone call from Vishwanath's daughter, sighting that he is missing since two days. Then, he confronts Dass and learns that he had kidnapped him for more money. Sai Ram feels guilty for his action and decides to find Vishwanath. Meanwhile, Abhiram-Aira's friendship develops and they are always seen together.