150 years ago, Lilith Silver is mortally wounded as she attempts to avenge the dueling death of her lover by Sir Sethane Blake. Enamored by her spirit, Sir Sethane reveals himself to be a vampire and grants Lilith the gift (and curse) of eternal life as a vampire. Today, Lilith moves through the city as a contract killer hired to eliminate all members of the mysterious and evil Masonic "Illuminati" sect, the leader of which, not coincidentally, is Sir Sethane. Clad in black latex and armed with a coffin full of weaponry, the vampiric hitwoman hunts down her targets while the police close in on her trail, desperate to end the carnage.