An artist named Hideo is painting his girlfriend Tomie (Miki Sakai), but she dismisses it as a poor painting and he kills her in a jealous rage with an art knife and his two friends Shunsuke and Takumi help him bury her. When the three friends are at a party Tomie shows up and the artist kills himself in the bathroom. Tomie latches onto Shunsuke and his mother kills Tomie and they cut her up together in an unnatural ecstasy. They then burn her head, which has already started to regenerate and has some crude limbs for locomotion. The portrait of Tomie allows for her regeneration, as her supernatural blood mixed with the pigments. Takumi's girlfriend Hitomi gets possessed by Tomie, in a rather viral fashion. In a fit of jealousy, the two Tomies try to eliminate the other.