Kate Holbrook (Tina Fey) is a successful single businesswoman who has always put her career before her personal life. Now in her late thirties, she finally decides to have her own child, but her plans are dampened when she discovers she has a minuscule chance of becoming pregnant because her uterus is T-shaped uterus. Also denied the chance to adopt, Kate hires an immature, obnoxious, South Philadelphia woman named Angie Ostrowski (Amy Poehler) to become her surrogacy.