In 1832, Jim Deakins (Kirk Douglas) is travelling in the wilderness when he encounters an initially hostile Boone Caudill (Dewey Martin (actor)). However, they soon become good friends and head together to St. Louis on the Missouri River in search of Boone's uncle, Zeb Calloway (Arthur Hunnicutt). They find him when they are tossed in jail for brawling with fur traders of the Missouri River Company. When 'Frenchy' Jourdonnais (Steven Geray) comes to bail Zeb out, Zeb talks him into paying for Jim and Boone too.