Paul Lavond (Barrymore), who was wrongly convicted of robbing his own Paris bank and killing a night Security guard more than seventeen years ago, escapes Devil's Island with Marcel (Henry B. Walthall), a scientist who is trying to create a formula to reduce people to one-sixth of their original size. The intended purpose of the formula is to make the Earth's limited resources last longer for an ever-growing population. The scientist dies after their escape.