The adventurous and creative third-grader Ramona Quimby (Joey King) often finds herself in trouble at school and at home, usually with her best friend, Howie (Jason Spevack). When her father Robert (John Corbett (actor)) loses his job and the family falls into severe debt, Ramona's efforts to earn money end up backfiring in humorous ways. She repeatedly embarrasses her older sister, Beatrice (Selena Gomez), calling her by her family nickname, "Beezus", in front of Beatrice's crush, the paperboy Henry Huggins (Hutch Dano). After working as an executive in a storage company since Beezus's birth, Robert causes quarrels with his wife and the girls' mother Dorothy (Bridget Moynahan) when he decides to pursue a creative career.