Doctor Jumba Jookiba, a mad scientist, is on trial by the Galactic Federation for illegal genetic experimentation, evidenced by his creation "Experiment 626", a small blue sentient creature with unparalleled intelligence and strength, but also a propensity to cause chaos. Jumba is imprisoned while the creature is sentenced to exile on a desert asteroid. "626" manages to escape on a red police spaceship, and activates the hyperdrive, causing its guidance systems to malfunction and randomly set a course for Earth. 626 crash-lands on Kauai only to be knocked unconscious by three passing trucks and taken to an animal shelter. The Grand Councilwoman dispatches Jumba and Agent Pleakley, the Council's expert on Earth, to the planet to have 626 captured discreetly, because Earth is the habitat for the "endangered" mosquito and humans are described as being unable to handle an alien encounter.