Melvin Junko (originally Ferd) has been transformed into the superhero known as the Toxic Avenger. He has made Tromaville a safe place again. However, with no more evil to destroy, Melvin has suffered depression until his blind girlfriend Claire (originally Sara) has gotten him a job at the Tromaville Center for the Blind. When the lunch bell rings, all of the residents enter the building when a mysterious limo pulls up. Inside the limo are the Chairman of Apocalypse Inc. and his number one, Malfaire. Apocalypse Inc. is a New York-based chemical company that finds Tromaville to be the perfect home for its new takeover site. However, they know all about The Toxic Avenger. The Chairman hires a member of his team disguised as a PUS deliveryman to deliver a bomb into the center. Claire escapes in time upon learning of the bomb, but everyone else is killed. However, when the deliveryman and an Apocalypse construction worker arrive to begin their takeover, the Toxic Avenger emerges from the rubble and kills the duo. This leads to an all-out assault by various members of Apocalypse Inc. with the Chairman and Malfaire watching. Toxie easily defeats the group of thugs, either killing them or in the case of one, making him run away. The only survivors of the explosion are Toxie, Claire, and a blind mom and her infant daughter.