The film begins with Buddha (Field Cate) and his owner Sam (Nolan Gould) star-gazing, when Sam makes a wish to touch the moon. The next day is his school field trip to Vision Enterprises, in which students participate in a special viewing of a test launch of the Vision One spacecraft. However, Sam has to leave Buddha at home to attend, so Buddha secretly escapes to meet up with the other buddies; Rosebud (Liliana Mumy), Budderball (Josh Flitter), B-Dawg (Skyler Gisondo), and Mudbud (Henry Hodges), and invites them to join his own spectatorship of the test launch. In a quick effort, they hide in the back of the school bus as it drives to the launch site of Vision Enterprises. On a tour with Dr. Finkel (Kevin Weisman), students see an automatic outfitter that Sam uses. The dogs, not far behind, come across the machine themselves and use it to equip suits before deciding to view the interior of the Vision 1 outside. At the Vision Enterprises' control center, "Mission Control", Pi (Bill Fagerbakke) confirms the ship is now prepared to launch. The Buddies conveniently place themselves in the seats when they become sealed in. Astro (Ali Hillis), the remote pilot, activates the shuttle, and the Vision 1 propels into the outer atmosphere with the Buddies.