The film centers on two main characters: Lazarus Redd (Samuel L. Jackson), a deeply religious farmer and former blues guitarist, and Rae Doole (Christina Ricci), a young Sex addiction. Lazarus' wife and his brother were having an affair, which has left him bitter and angry. Rae's boyfriend Ronnie Morgan (Justin Timberlake) leaves for deployment with the 196th Field Artillery Brigade, United States National Guard, and in his absence, she indulges in bouts of promiscuity and drug use. During one of Rae's binges, Ronnie's friend Gill Morton (Michael Raymond-James) tries to take advantage of her. She laughs at his advances, comparing him unfavorably with another man, and he severely beats her. Believing she's dead, Gill dumps Rae and leaves her by the side of the road wearing only a shirt and panties and drives away.