A fictionalised version of author R. Chetwynd-Hayes (John Carradine) is approached on a city street by a strange man (Vincent Price) who turns out to be a starving vampire named Eramus. Eramus bites the writer, and in gratitude for the small "donation", takes his (basically unharmed but bewildered) victim to the titular club, which is a covert gathering place for a multitude of supernatural creatures. In between the club's unique music and dance performances, Eramus introduces three stories about his fellow creatures of the night.